The former World No. 3 owns a 44-13 record at the season’s final major. He lifted his third Grand Slam trophy at Flushing Meadows five years ago, completing an impressive run by defeating World No. 1 Novak Djokovic in the final.
Wawrinka has advanced to at least the quarter-finals of the US Open in six of his past nine appearances. In his most recent showing two years ago, he made the last eight before losing against eventual finalist Daniil Medvedev.
The Swiss star has not competed since Doha in March. Following Wawrinka’s withdrawal, former World No. 1 and 2012 champion Andy Murray moves into the main draw.