Eddie Jones resisted calls for the return of his England old-guard with Billy Vunipola, Mako Vunipola, Jamie George and George Ford all out of his official autumn squad.
In a 34-man group set for Tests next month against Tonga, Australia and South Africa, Jones is setting his revolution in motion, dropping a quartet with 276 caps-worth of experience.
Maro Itoje is the only Saracens forward included, with both Vunipolas and George left out.
Eddie Jones has wielded the axe in his England squad for this year’s autumn internationals
Both Mako Vunipola (left) and Billy Vunipola (right) are out with Jamie George and George Ford
Marcus Smith, as Sportsmail revealed, looks set for the No 10 shirt after his sublime form for Harlequins
Sarries boss Mark McCall said he would be ‘amazed’ if those were omitted after they starred in the 71-17 thrashing of Bath on Sunday – and they have been.
As Sportsmail revealed, Nic Dolly is in with George out; the Leicester hooker born in Australia has scored five tries in five Premiership games for Tigers in a superb start to the season.
Jamie Blamire from Newcastle is also preferred to George, with a fitness update due on Exeter hooker Luke Cowan-Dickie, who limped off against Wasps on Saturday.
With no Billy Vunipola, Sam Simmonds, Alex Dombrandt and Callum Chick are the out-and-out No 8s with Tom Curry expected to be used there too.
Marcus Smith, as Sportsmail revealed, looks set for the No 10 shirt. He is in as the main fly-half option, as Ford misses out, with Harry Randall and uncapped Raffi Quirke vying with Ben Youngs for the scrum-half berth.
In the backs Tommy Freeman, the 20-year-old Northampton Saints full-back, is included, with no place for Harlequins’ Australian-qualified Louis Lynagh, who was in the wider squad picked last month.
Newcastle’s wing Adam Radwan is picked alongside stalwarts Jonny May and Anthony Watson
Tommy Freeman (centre), the 20-year-old Northampton full-back, is included in the squad
Jones said: ‘This is a young but very good, talented squad, who have all earned their places. It is one of the most competitive squads I have ever picked.
‘There are a number of disappointed players who haven’t been selected, but they know what they need to do and no door is closed to any player.
‘We’re looking forward to three tough Test matches. Tonga always play a strong, physical game and Australia and South Africa have had extended periods together and will be a good challenge for us.
‘Our aim each week will be to get better and better as we work towards the Rugby World Cup in 2023.’
Mark Atkinson, retained from Jones’ 45-man squad from September, is the other uncapped back included.
Hooker Nic Dolly is in after scoring five tries in five league games for Leicester this season
At prop, in-form Harlequins man Joe Marler could get a first England cap since last December
Newcastle’s flying wing Adam Radwan is picked alongside stalwarts Jonny May and Anthony Watson, with Leicester’s Freddie Steward and Saracens’ Max Malins options at full-back with George Furbank and Freeman from Saints. Henry Slade and Manu Tuilagi will battle for centre shirts.
The last man to captain England, Lewis Ludlow from Gloucester, does not make the squad despite a strong start to the season for the Cherry & Whites.
Lewis Ludlam, at Northampton, does though, joining club-mate Courtney Lawes, Sam Underhill from Bath, Sale’s Tom Curry and Leicester’s George Martin as back-row options.
At prop Joe Marler could win his first England cap since last December, joined by Trevor Davison, Will Stuart, Kyle Sinckler and Ellis Genge. In the second row Jonny Hill and Charlie Ewels are retained.
ENGLAND’S AUTUMN SQUAD
FORWARDS: Jamie Blamire (Newcastle Falcons, 2 caps) Callum Chick (Newcastle Falcons, 2 caps) Luke Cowan-Dickie (Exeter Chiefs, 31 caps) Tom Curry (Sale Sharks, 33 caps) Trevor Davison (Newcastle Falcons, 1 cap) Nic Dolly (Leicester Tigers, uncapped) Alex Dombrandt (Harlequins, 1 cap) Charlie Ewels (Bath Rugby, 23 caps) Ellis Genge (Leicester Tigers, 30 caps) Jonny Hill (Exeter Chiefs, 9 caps) Maro Itoje (Saracens, 48 caps) Courtney Lawes (Northampton Saints, 87 caps) Lewis Ludlam (Northampton Saints, 10 caps) Joe Marler (Harlequins, 72 caps) George Martin (Leicester Tigers, 1 cap) Sam Simmonds (Exeter Chiefs, 7 caps) Kyle Sinckler (Bristol Bears, 44 caps) Will Stuart (Bath Rugby, 12 caps) Sam Underhill (Bath Rugby, 24 caps)
BACKS: Mark Atkinson (Gloucester Rugby, uncapped) Owen Farrell (Saracens, 93 caps) Tommy Freeman (Northampton Saints, uncapped) George Furbank (Northampton Saints, 4 caps) Max Malins (Saracens, 8 caps) Jonny May (Gloucester Rugby, 66 caps) Raffi Quirke (Sale Sharks, uncapped) Adam Radwan (Newcastle Falcons, 1 cap) Harry Randall (Bristol Bears, 2 caps) Henry Slade (Exeter Chiefs, 40 caps) Marcus Smith (Harlequins, 2 caps) Freddie Steward (Leicester Tigers, 2 caps) Manu Tuilagi (Sale Sharks, 43 caps) Anthony Watson (Bath Rugby, 51 caps) Ben Youngs (Leicester Tigers, 109 caps)